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DB1055

Chemical Structure : DB1055

CAS No.: 869767-86-2

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DB1055 (DB-1055, DB 1055)

Catalog No.: PC-36000Not For Human Use, Lab Use Only.

DB1055 (DB-1055, DB 1055) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DB1055 (DB-1055, DB 1055) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.
    DB1055 directly binds to HOXA9-cognate sequence with Kd value of 5.5 nM (HBS sequence).
    DB1055 alters HOXA9-mediated transcription, cell survival and cell cycle inHOXA9-mediated HOXA9-expressing murine MigA9 cell line.

    Physicochemical Properties

    M.Wt 354.417
    Formula C21H18N6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3'-carbamimidoyl-[1,1'-biphenyl]-4-yl)-1H-benzo[d]imidazole-6-carboximidamide

    References

    1. Depauw S, et al. J Med Chem. 2019 Jan 15. doi: 10.1021/acs.jmedchem.8b01448.

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