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Chemical Structure : DB1055
Catalog No.: PC-36000Not For Human Use, Lab Use Only.
DB1055 (DB-1055, DB 1055) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.
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DB1055 (DB-1055, DB 1055) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.
DB1055 directly binds to HOXA9-cognate sequence with Kd value of 5.5 nM (HBS sequence).
DB1055 alters HOXA9-mediated transcription, cell survival and cell cycle inHOXA9-mediated HOXA9-expressing murine MigA9 cell line.
| M.Wt | 354.417 | |
| Formula | C21H18N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Depauw S, et al. J Med Chem. 2019 Jan 15. doi: 10.1021/acs.jmedchem.8b01448.
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