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DB818

Chemical Structure : DB818

CAS No.: 790241-43-9

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DB818 (DB-818, DB 818)

Catalog No.: PC-35999Not For Human Use, Lab Use Only.

DB818 (DB-818, DB 818) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DB818 (DB-818, DB 818) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.
    DB818 directly binds to HOXA9-cognate sequence with Kd value of 4.6 nM (HBS sequence).
    DB818 alters HOXA9-mediated transcription, cell survival and cell cycle inHOXA9-mediated HOXA9-expressing murine MigA9 cell line.

    Physicochemical Properties

    M.Wt 360.439
    Formula C19H16N6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(5-(4-carbamimidoylphenyl)thiophen-2-yl)-1H-benzo[d]imidazole-6-carboximidamide

    References

    1. Depauw S, et al. J Med Chem. 2019 Jan 15. doi: 10.1021/acs.jmedchem.8b01448.

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