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Chemical Structure : DBK-1154
CAS No.: 1809068-70-9
Catalog No.: PC-62749Not For Human Use, Lab Use Only.
SMAP-2 (DT-1154, DBK1154) is an orally bioavailable small molecule activator of PP2A, binds to PP2A Aα scaffold subunit and inhibits KRAS-driven tumor growth both in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SMAP-2 (DT-1154, DBK1154) is an orally bioavailable small molecule activator of PP2A, binds to PP2A Aα scaffold subunit and inhibits KRAS-driven tumor growth both in vitro and in vivo.
SMAP-2 (DT-1154, DBK1154) decreases cellular viability and clonogenicity and induces apoptosis in castrate-resistant prostate cancer (CRPC) cells.
SMAP-2 (DT-1154, DBK1154) significantly changes the phosphoproteome, including dephosphorylation of full-length and truncated isoforms of the AR and downregulation of its regulatory kinases.
SMAP-2 (DT-1154, DBK1154) exhibits efficacy comparable to enzalutamide in vivo.
| M.Wt | 532.578 | |
| Formula | C27H27F3N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((1S,2S,3R)-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-2-hydroxycyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide |
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1. Sangodkar J, et al. J Clin Invest. 2017 Jun 1;127(6):2081-2090.
2. McClinch K, et al. Cancer Res. 2018 Jan 22. pii: canres.0123.2017.
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