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Chemical Structure : DBPR108
CAS No.: 1186426-66-3
Catalog No.: PC-43097Not For Human Use, Lab Use Only.
Prusogliptin (DBPR108) is a potent, selective, orally bioavailable and long-acting inhibitor of DPP4 with IC50 of 15 nM, >3,000-fold selectivity over DPP8, DPP9, FAP and DPP-II.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $178 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Prusogliptin (DBPR108) is a potent, selective, orally bioavailable and long-acting inhibitor of DPP4 with IC50 of 15 nM, >3,000-fold selectivity over DPP8, DPP9, FAP and DPP-II.
Prusogliptin (DBPR108) exhibits excellent human plasma DPP-IV inhibition with IC50 of 5 nM.
Prusogliptin (DBPR108) suppresses blood glucose elevation in vivo, demonstrates potential treatment of type 2 diabetes mellitus.
| M.Wt | 324.3937 | |
| Formula | C16H25FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyrrolidinecarbonitrile, 1-[2-[[1,1-dimethyl-3-oxo-3-(1-pyrrolidinyl)propyl]amino]acetyl]-4-fluoro-, (2S,4S)- |
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1. Yeh TK, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3596-600.
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