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Chemical Structure : DBPR211
CAS No.: 1429239-98-4
Catalog No.: PC-43210Not For Human Use, Lab Use Only.
DBPR211 (BPRCB1184, CB1-IN-4) is a potent, selective, peripherally restricted cannabinoid-1 (CB1) receptor antagonist with Ki of 0.3 nM, EC50 of 3.0 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $728 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DBPR211 (BPRCB1184, CB1-IN-4) is a potent, selective, peripherally restricted cannabinoid-1 (CB1) receptor antagonist with Ki of 0.3 nM, EC50 of 3.0 nM.
DBPR211 possess a low probability to cross BBB as a peripherally restricted CB1R antagonist, exhibits significant weight-loss efficacy in DIO mice.
DBPR211 also displays 163 clean off-target profiles and potential for treating obesity and the related metabolic syndrome.
| M.Wt | 751.6688 | |
| Formula | C33H31Cl2F3N6O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-N-1-piperidinyl-4-[[(1-pyrrolidinylsulfonyl)amino]methyl]-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]- |
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1. Chang CP, et al. J Med Chem. 2013 Dec 27;56(24):9920-33.
2. Chun-Ping Chang, et al. Bioorg Med Chem. 2019 Jan 1;27(1):216-223.
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