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Chemical Structure : DC-5163
Catalog No.: PC-22460Not For Human Use, Lab Use Only.
DC-5163 is a smal molecule glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with IC50 of 176.3 nM, inhibits glucose uptake, reduces lactic acid production, selectively inhibits cancer cell proliferation.
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DC-5163 is a smal molecule glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with IC50 of 176.3 nM, inhibits glucose uptake, reduces lactic acid production, selectively inhibits cancer cell proliferation.
DC-5163 interacts with GAPDH protein with KD of 3.192 uM in microscale thermophoresis assays.
DC-5163 inhibits MDA-MB-231 cell proliferation with an IC50 of 99.22 μM at 48 h and 52.09 μM at 72 h, induces apoptosis and suppressed glycolysis.
| M.Wt | 361.89 | |
| Formula | C18H20ClN3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li T, et al. Bioorg Chem. 2020 Mar;96:103620.
2. Zhang YQ, et al. Cancer Cell Int. 2024 May 29;24(1):188.
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