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DC-5163

Chemical Structure : DC-5163

CAS No.: 897771-47-0

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DC-5163 (DC5163)

Catalog No.: PC-22460Not For Human Use, Lab Use Only.

DC-5163 is a smal molecule glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with IC50 of 176.3 nM, inhibits glucose uptake, reduces lactic acid production, selectively inhibits cancer cell proliferation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DC-5163 is a smal molecule glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with IC50 of 176.3 nM, inhibits glucose uptake, reduces lactic acid production, selectively inhibits cancer cell proliferation.
DC-5163 interacts with GAPDH protein with KD of 3.192 uM in microscale thermophoresis assays.
DC-5163 inhibits MDA-MB-231 cell proliferation with an IC50 of 99.22 μM at 48 h and 52.09 μM at 72 h, induces apoptosis and suppressed glycolysis.

Physicochemical Properties

M.Wt 361.89
Formula C18H20ClN3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-benzyl-N-(3-chloro-4-methoxyphenyl)imidazolidine-1-carbothioamide

References

1. Li T, et al. Bioorg Chem. 2020 Mar;96:103620.

2. Zhang YQ, et al. Cancer Cell Int. 2024 May 29;24(1):188.

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