Chemical Structure : DCLK1 inhibitor 12n
CAS No.:
2803885-35-8
DCLK1 inhibitor 12n
Catalog No.: PC-25592Not For Human Use, Lab Use Only.
DCLK1 inhibitor 12n is a potent, selective Doublecortin-like Kinase 1 (DCLK1) inhibitor with IC50 of 58 nM, exhibits notable DCLK1 inhibitory activity at the cellular level with IC50 of 25 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DCLK1 inhibitor 12n is a potent, selective Doublecortin-like Kinase 1 (DCLK1) inhibitor with IC50 of 58 nM, exhibits notable DCLK1 inhibitory activity at the cellular level with IC50 of 25 nM.
DCLK1 inhibitor 12n decreases the phosphorylation level of IKK in RAW264.7 cells, induces down-regulation and up-regulation for downstream p-IκB-α and IκB-α levels respectively.
DCLK1 inhibitor 12n shows anti-inflammatory activity test in vitro.
DCLK1 inhibitor 12n (5 mg/kg) demonstrated superior therapeutic efficacy in ALI and sepsis models.
Physicochemical Properties
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M.Wt
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541.66
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Formula
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C30H35N7O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((2-Methoxy-4-(3,9-diazaspiro[5.5]undecane-3-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one
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References
1. Shanchao Wu, et al. J Med Chem. 2025 Oct 7. doi: 10.1021/acs.jmedchem.5c01811.
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