Chemical Structure : DD1E5
CAS No.:
625376-24-1
DD1E5
Catalog No.: PC-27827Not For Human Use, Lab Use Only.
DD1E5 is a competitive inhibitor of dimethylarginine dimethylaminohydrolase1 (DDAH1) with Ki of 2.05 uM, inhibits cancer cell proliferation and a subsequent decrease in NO production with ADMA accumulation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DD1E5 is a competitive inhibitor of dimethylarginine dimethylaminohydrolase1 (DDAH1) with Ki of 2.05 uM, inhibits cancer cell proliferation and a subsequent decrease in NO production with ADMA accumulation.
DD1E5 reversed the elevated VEGF, c-Myc, HIF-1α, and iNOS levels induced by exogenous DDAH1 overexpression in PCa cells.
DD1E5 significantly increased intracellular levels of ADMA and reduced NO production.
DD1E5 abrogated the secretion of angiogenic factors (bFGF and IL-8) into conditional media.
DD1E5 inhibited in vivo growth of xenograft tumors derived from PCa cells with DDAH1 overexpression, by reducing tumor endothelial content represented with low CD31 expression.
Physicochemical Properties
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M.Wt
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400.44
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Formula
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C16H15F3N4OS2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-amino-6-tert-butyl-N-(1,3-thiazol-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide
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References
1. Kami Reddy KR, et al. ACS Comb Sci. 2019 Apr 8;21(4):241-256.
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