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Chemical Structure : DDO-5936
CAS No.: 2355377-13-6
Catalog No.: PC-73076Not For Human Use, Lab Use Only.
DDO-5936 (DDO5936) is a cell-active, specidic small-molecule inhibitor of Hsp90-Cdc37 protein-protein interaction (PPI) without ATPase inhibition, binds to Hsp 90 with Kd of 3.86 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $388 | In stock | |
| 50 mg | $958 | In stock | |
| 100 mg | $1580 | In stock | |
| 1 g | Get quote |
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DDO-5936 (DDO5936) is a cell-active, specidic small-molecule inhibitor of Hsp90-Cdc37 protein-protein interaction (PPI) without ATPase inhibition, binds to Hsp90 with Kd of 3.86 uM.
DDO-5936 exhibits little effect on Hsp90 ATPase activity, DDO-5936 targets a surface binding site on Hsp90 to inhibit the Hsp90-Cdc37 PPI.
DDO-5936 binding affinity was remarkably decreased for the E47A mutant (KD> 100 μM) and moderately lower for the R46A mutant (KD =6.53 μM) and Q133A mutant (KD=5.18 μM).
DDO-5936 represses cell proliferation through a strong correlation with the Hsp90-Cdc37 expression level, and selectively down-regulates kinase clients of Hsp90, arrests the cell cycle in HCT116 cells in a Cdc37-dependent manner.
DDO-5936 (50-100 mg/kg, ip) dose-dependently impairs the growth of xenografted HCT116 cells in nude mice.
| M.Wt | 495.598 | |
| Formula | C25H29N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(mesitylsulfonyl)-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)glycine |
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1. Lei Wang, et al. Sci Adv. 2019 Sep 18;5(9):eaax2277.
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