Chemical Structure : DDO-6079
CAS No.:
2648334-53-4
DDO-6079
(DDO6079)
Catalog No.: PC-23505Not For Human Use, Lab Use Only.
DDO-6079 is a specific, allosteric small-molecule CDC37 inhibitor, binds to an allosteric site on the CDC37 M-terminal domain with ITC Kd of 1.03 uM, inhibits the binding between HSP90-CDC37 and CDC37-kinase.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DDO-6079 is a specific, allosteric small-molecule CDC37 inhibitor, binds to an allosteric site on the CDC37 M-terminal domain with ITC Kd of 1.03 uM, inhibits the binding between HSP90-CDC37 and CDC37-kinase.
DDO-6079 simultaneously inhibits HSP90-CDC37 and CDC37-CDK4/6 chaperone comple.
DDO-6079 inhibits the formation of the HSP90-CDC37-CDK4/6 complex in cells in an allosteric manner and selectively inhibits the maturation of multiple oncogenic kinases escape from the heat shock response (HSR).
DDO-6079 exhibits no effects on HSR related protein (HSF-1, HSP70, HSP40 or HSP27).
DDO-6079 shows antiproliferation activity and decreased the thermostability of CDK6 to reverse the resistance of colorectal cancer cells to palbociclib.
DDO-6079 reversed the resistance of CDK6 to palbociclib (a successful CDK4/6 inhibitor) in colorectal cancer cells and exhibited efficacy in vivo.
Physicochemical Properties
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M.Wt
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340.76
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Formula
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C18H13ClN2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-chloro-2-hydroxy-N-(2-phenoxypyridin-4-yl)benzamide
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References
1. Zhang L, et al. Angew Chem Int Ed Engl. 2024 Nov 24:e202413618.
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