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DDO-6600

Chemical Structure : DDO-6600

CAS No.: 2640292-37-9

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DDO-6600 (DDO 6600)

Catalog No.: PC-72553Not For Human Use, Lab Use Only.

DDO-6600 (DDO 6600) is a potent, selective, covalent inhibitor of Hsp90, covalently modifies Cys598 on Hsp90 and disrupts the interaction between Hsp90 and Cdc37 (IC50=6.67 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DDO-6600 (DDO 6600) is a potent, selective, covalent inhibitor of Hsp90, covalently modifies Cys598 on Hsp90 and disrupts the interaction between Hsp90 and Cdc37 (IC50=6.67 uM).
    DDO-6600 exhibited antiproliferative activities against multiple tumor cells without inhibiting ATPase activity.
    DDO-6600 induced the degradation of kinase client proteins in multiple tumor cell lines, promoted apoptosis, and inhibited cell motility.
    DDO-6600 exhibits antitumor activity in HCT-116 mouse models.

    Physicochemical Properties

    M.Wt 428.536
    Formula C26H28N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-1-(3-(3-(3,4-dimethylphenyl)-1-phenyl-1H-pyrazol-4-yl)acryloyl)piperidine-2-carboxamide

    References

    1. Li Li, et al. Cell Chem Biol. 2021 Oct 21;28(10):1446-1459.e6.

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