Catalog No.: PC-22478Not For Human Use, Lab Use Only.
DDO-7263 is a a potent small molecule Nrf2-ARE activator, inhibits NLRP3 inflammasome activationand shows neuroprotective effect, upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome.
DDO-7263 is a a potent small molecule Nrf2-ARE activator, inhibits NLRP3 inflammasome activationand shows neuroprotective effect, upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome. DDO-7263 protects PC12 neurons from H2O2-induced oxidative damage. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 significantly inhibited NLRP3 activation, cleaved caspase-1 production and IL-1β protein expression in ATP-LPS-exposed THP-Ms cells. DDO-7263 improves the behavioral abnormalities induced by MPTP in mice, significantly attenuates chemically induced dopaminergic neuron loss of tyrosine hydroxylase (TH) in the substantia nigra (SN) and striatum of the mouse brain and inhibited the secretion of inflammatory factors.
