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Chemical Structure : DETQ
Catalog No.: PC-60735Not For Human Use, Lab Use Only.
DETQ is a novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM.
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DETQ is a novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM.
DETQ induces a 21-fold leftward shift in the cAMP response to dopamine in HEK293 cells, 30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor.
DETQ robustly (∼10-fold) increases locomotor activity in habituated hD1 mice (3-20 mg/kg), also acts synergistically with L-DOPA to reverse the strong hypokinesia caused by reserpine.
| M.Wt | 422.346 | |
| Formula | C22H25Cl2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Svensson KA, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):117-128.
2. Bruns RF, et al. Neuropharmacology. 2018 Jan;128:351-365.
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