Catalog No.: PC-38338Not For Human Use, Lab Use Only.
DF3016A (DF 3016A) is a potent and selective C5aR inhibitor with IC50 of 50 nM (C5a-induced human PMN migration and IC50 of 45 and 37 nM against rat and mouse C5aR, respectively.
DF3016A (DF 3016A) is a potent and selective C5aR inhibitor with IC50 of 50 nM (C5a-induced human PMN migration and IC50 of 45 and 37 nM against rat and mouse C5aR, respectively.
DF3016A exhibited a high degree of selectivity with no effect on PMN migration induced by other leukocyte activators such as CXCL8, CXCL1, CCL3, fMLP, CXCL12, and on LPS-induced PGE2 accumulation at 10 uM.
DF3016A protects neuronal viability by restoring intracellular calcium levels, thus opposing the increase in pro-inflammatory cytokine levels and miR-181 expression in rat model of neuroinflammatory injury.
DF3016A also inhibits osteoclast degradation activity through inhibition of C5aR signal transduction and transcription.
