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Chemical Structure : DF3016A
Catalog No.: PC-38338Not For Human Use, Lab Use Only.
DF3016A (DF 3016A) is a potent and selective C5aR inhibitor with IC50 of 50 nM (C5a-induced human PMN migration and IC50 of 45 and 37 nM against rat and mouse C5aR, respectively.
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DF3016A (DF 3016A) is a potent and selective C5aR inhibitor with IC50 of 50 nM (C5a-induced human PMN migration and IC50 of 45 and 37 nM against rat and mouse C5aR, respectively.
DF3016A exhibited a high degree of selectivity with no effect on PMN migration induced by other leukocyte activators such as CXCL8, CXCL1, CCL3, fMLP, CXCL12, and on LPS-induced PGE2 accumulation at 10 uM.
DF3016A protects neuronal viability by restoring intracellular calcium levels, thus opposing the increase in pro-inflammatory cytokine levels and miR-181 expression in rat model of neuroinflammatory injury.
DF3016A also inhibits osteoclast degradation activity through inhibition of C5aR signal transduction and transcription.
| M.Wt | 362.31 | |
| Formula | C13H10F3N6NaS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rosa D'Angelo, et al. Biomed Pharmacother. 2020 Mar;123:109764.
2. Laura Brandolini, et al. Neurotox Res. 2019 Jul;36(1):163-174.
3. Grannonico M, et al. Brain Res. 2020 Dec 1;1748:147057.
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