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DFP00173

Chemical Structure : DFP00173

CAS No.: 672286-03-2

DFP00173 (DFP-00173)

Catalog No.: PC-36121Not For Human Use, Lab Use Only.

DFP00173 (DFP 00173) is a potent and selective aquaporin-3 (AQP3) inhibitor with IC50 of 0.9-1.4 uM for mouse and human AQP3, with low efficacy toward mouse AQP7 and AQP9.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DFP00173 (DFP 00173) is a potent and selective aquaporin-3 (AQP3) inhibitor with IC50 of 0.9-1.4 uM for mouse and human AQP3, with low efficacy toward mouse AQP7 and AQP9.
DFP00173 inhibits glycerol permeability in erythrocytes with IC50 of 0.2 uM, agreed well with the inhibition of water permeability in CHO cells.

Physicochemical Properties

M.Wt 332.155
Formula C11H7Cl2N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(2,6-dichlorophenyl)-3-(5-nitrothiophen-3-yl)urea

References

1. Sonntag Y, et al. J Biol Chem. 2019 Mar 11. pii: jbc.RA118.006083. doi: 10.1074/jbc.RA118.006083.

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