Chemical Structure : DG-172 dihydrochloride
CAS No.:
1361504-77-9
DG-172 dihydrochloride
(DG172)
Catalog No.: PC-45697Not For Human Use, Lab Use Only.
DG-172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50= 27 nM) and potent inverse agonistic properties.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
DG-172 dihydrochloride is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50= 27 nM) and potent inverse agonistic properties.
DG-172 dihydrochloride inhibits agonist-induced activity of PPARβ/δ, enhances transcriptional corepressor recruitment.
DG-172 dihydrochloride down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50= 9.5 nM); orally bioactive.
Physicochemical Properties
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M.Wt
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455.2188
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Formula
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C20H22BrCl2N3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Benzeneacetonitrile, 2-bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]-, hydrochloride (1:2), (αZ)-
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References
1. Lieber S, et al. J Med Chem. 2012 Mar 22;55(6):2858-68.
2. Lieber S, et al. Mol Pharmacol. 2015 Feb;87(2):162-73.
3. Adhikary T, et al. Oncogene. 2013 Oct 31;32(44):5241-52.
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