Chemical Structure : DHC-156
CAS No.:
DHC-156
(DHC156)
Catalog No.: PC-21752Not For Human Use, Lab Use Only.
DHC-156 is a covalent small molecule inhibitor of oncogenic transcription factor brachyury, selectively binds to brachyury, DHC-156 is potent brachyury downmodulator with DC50 of 4.1 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DHC-156 is a covalent small molecule inhibitor of oncogenic transcription factor brachyury, selectively binds to brachyury, DHC-156 is potent brachyury downmodulator with DC50 of 4.1 uM.
DHC-156 is a chemical analog of afatinib that lacks kinase inhibition activity, whereas afatinib is highly reactive with multiple kinases.
DHC-156 (10 uM) significantly decreased the brachyury fluorescent by immunofluorescent staining of brachyury in CH-22 cells.
DHC-156 downmodulates brachyury post-translationally, displays loss of brachyury phenotyp, results in an irreversible impairment of chordoma tumor cell growth.
Physicochemical Properties
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M.Wt
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492.47
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Formula
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C24H24F4N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-4-(dimethylamino)-N-(1-((4-fluoro-3-(2,2,2-trifluoroethoxy)phenyl)amino)-6-methoxyisoquinolin-7-yl)but-2-enamide
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References
1. Chase DH, et al. Angew Chem Int Ed Engl. 2024 Feb 13:e202316496.
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