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Chemical Structure : DHC-156
Catalog No.: PC-21752Not For Human Use, Lab Use Only.
DHC-156 is a covalent small molecule inhibitor of oncogenic transcription factor brachyury, selectively binds to brachyury, DHC-156 is potent brachyury downmodulator with DC50 of 4.1 uM.
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DHC-156 is a covalent small molecule inhibitor of oncogenic transcription factor brachyury, selectively binds to brachyury, DHC-156 is potent brachyury downmodulator with DC50 of 4.1 uM.
DHC-156 is a chemical analog of afatinib that lacks kinase inhibition activity, whereas afatinib is highly reactive with multiple kinases.
DHC-156 (10 uM) significantly decreased the brachyury fluorescent by immunofluorescent staining of brachyury in CH-22 cells.
DHC-156 downmodulates brachyury post-translationally, displays loss of brachyury phenotyp, results in an irreversible impairment of chordoma tumor cell growth.
| M.Wt | 492.47 | |
| Formula | C24H24F4N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chase DH, et al. Angew Chem Int Ed Engl. 2024 Feb 13:e202316496.
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