Catalog No.: PC-72538Not For Human Use, Lab Use Only.
GSK983 (GSK-983) is a potent small-molecule antiviral agent, and a potent, competitive inhibitor of dihydroorotate dehydrogenase (DHODH) with Ki of 403 nM.
GSK983 (GSK-983) is a potent small-molecule antiviral agent, and a potent, competitive inhibitor of dihydroorotate dehydrogenase (DHODH) with Ki of 403 nM.
GSK983 inhibits the growth of cell lines immortalized by HTLV-1, EBV, HPV, SV40 and Ad-5, with EC50 values in the range of 10-40 nM.
GSK983 induces either apoptosis or cytostasis at concentrations over 20 nM.
GSK983 also inhibits cell lines immortalized by non-viral mechanisms, but has little effect on primary cells.
GSK983 inhibited K562 cell growth with an IC50 of 21 nM, GSK983 treatment caused an accumulation of K562 cells in S phase.
GSK983 inhibits DHODH to block virus replication and cell proliferation.
GSK983 displayed a marked inhibitory effect on the proliferation of neuroblastoma cell lines with IC50 values from nanomoles to low micromoles.
