DHX8-IN-1 | DHX8 inhibitor | Probechem Biochemicals

Chemical Structure : DHX8-IN-1

DHX8-IN-1 (Compound 53)

Catalog No.: PC-27642Not For Human Use, Lab Use Only.

DHX8-IN-1 (Compound 53) is a potent, specific inhibitor of spliceosomal DEAH-box RNA helicase DHX8, inhibits DHX9 ATP-hydrolysis with IC50 of 43 nM in biochemical ADP-Glo assays, and 120 nM in RNA FA (fluorescence anisotropy) binding assays.

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Biological Activity

Physicochemical Properties

M.Wt	392.52
Formula	C23H24N2O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((2-(4-(isopropylamino)phenyl)-1-phenylethyl)thio)nicotinic acid

References

1. Read BJ, et al. J Med Chem. 2026 Aug 13;69(15):18277-18299.

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DHX8-IN-1 (Compound 53)

Biological Activity

Physicochemical Properties

References

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