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DI-1548

Chemical Structure : DI-1548

CAS No.: 2247060-97-3

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DI-1548 (DI 1548)

Catalog No.: PC-72230Not For Human Use, Lab Use Only.

DI-1548 (DI 1548) is a potent, selective and covalent DCN1 inhibitor with IC50 of 4.6 nM and Ki of <1 nM, does not bind to DCN3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DI-1548 (DI 1548) is a potent, selective and covalent DCN1 inhibitor with IC50 of 4.6 nM and Ki of <1 nM, does not bind to DCN3.
    DI-1548 could inhibit cullin 3 neddylation at concentration as low as 1 nM, which is 1000 times more potent than DI-591.
    DI-1548 selectively inhibit neddylation of cullin 3 in cells at low nanomolar concentrations and are 2-3 orders of magnitude more potent than our previously reported reversible DCN1 inhibitor DI-591.

    Physicochemical Properties

    M.Wt 597.819
    Formula C32H47N5O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((S)-2-cyclohexyl-2-((S)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamido)ethyl)-2-(morpholinomethyl)acrylamide

    References

    1. Haibin Zhou, et al. Nat Commun. 2021 May 11;12(1):2621.

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