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DI-591

Chemical Structure : DI-591

CAS No.: 2245887-38-9

DI-591 (DI591)

Catalog No.: PC-60017Not For Human Use, Lab Use Only.

DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2.
DI-591 displays no affinity against DCN3/4/5 (Ki>10 uM).
DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members.
DI-591 accumulates NRF2 protein and its transcriptional activation in cells.

Physicochemical Properties

M.Wt 585.808
Formula C31H47N5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-((S)-1-cyclohexyl-2-(3-morpholinopropanamido)ethyl)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamide

References

1. Zhou H, et al. Nat Commun. 2017 Oct 27;8(1):1150.

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