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DIMATE

Chemical Structure : DIMATE

CAS No.: 350229-29-7

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DIMATE (ALDH1 inhibitor DIMATE)

Catalog No.: PC-61351Not For Human Use, Lab Use Only.

DIMATE is a novel irreversible, competitive, isoform-specific ALDH1 inhibitor, displays cytotoxic activity on human AML cell lines with IC50 of 1-15 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DIMATE is a novel irreversible, competitive, isoform-specific ALDH1 inhibitor, displays cytotoxic activity on human AML cell lines with IC50 of 1-15 uM.
    DIMATE shows selective cytotoxicity in leukemic population enriched in LSCs, with no cytotoxicity for healthy hematopoietic stem cells.
    DIMATE promotes the accumulation of apoptogenic aldehydes leading to apoptosis and tumor growth inhibition in xenograft mouse models.

    Physicochemical Properties

    M.Wt 185.285
    Formula C9H15NOS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate

    References

    1. Pérez-Alea M, et al. Oncogene. 2017 Jun 5. doi: 10.1038/onc.2017.160.

    2. Venton, et al. Blood Cancer J. 2016 Sep 9;6(9):e469.

    3. Quash G, et al. Eur J Med Chem. 2008 May;43(5):906-16.

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