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Chemical Structure : DIMP53-1
Catalog No.: PC-61496Not For Human Use, Lab Use Only.
DIMP53-1 is a novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM.
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DIMP53-1 is a novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM.
DIMP 53-1 causes growth inhibition, mediated by p53 stabilization and upregulation of p53 transcriptional targets involved in cell cycle arrest and apoptosis.
DIMP 53-1 shows a p53-dependent antitumor activity in human tumor xenograft mice models; a novel p53 activator.
| M.Wt | 408.501 | |
| Formula | C27H24N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Soares J, et al. Mol Oncol. 2017 Jun;11(6):612-627.
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