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DIZ-3

Chemical Structure : DIZ-3

CAS No.: 2675490-72-7

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DIZ-3

Catalog No.: PC-38838Not For Human Use, Lab Use Only.

DIZ-3 is a dimeric aryl-substituted imidazole as a selective multimeric G-quadruplex (G4) ligand, intercalates into the G4-G4 interface, induces cell cycle arrest and apoptosis, and inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cell lines, via targeting telomeric multimeric G4.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DIZ-3 is a dimeric aryl-substituted imidazole as a selective multimeric G-quadruplex (G4) ligand, intercalates into the G4-G4 interface, induces cell cycle arrest and apoptosis, and inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cell lines, via targeting telomeric multimeric G4.

    Physicochemical Properties

    M.Wt 746.911
    Formula C46H44F2N8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-(5-(4-fluorophenyl)-2-(4-(4-(4-fluorophenyl)-5-(4-(4-methylpiperazin-1-yl)phenyl)-1H-imidazol-2-yl)phenyl)-1H-imidazol-4-yl)phenyl)-4-methylpiperazine

    References

    1. Ming-Hao Hu, et al. Eur J Med Chem. 2020 Jan 15;186:111891.

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