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Chemical Structure : DLCI-1 dihydrochloride
Catalog No.: PC-49015Not For Human Use, Lab Use Only.
DLCI-1 dihydrochloride is a potent and selective CYP2A6 inhibitor with IC50 of 17 nM, 15-765-fold selectivity other major hepatic CYP enzymes.
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DLCI-1 dihydrochloride is a potent and selective CYP2A6 inhibitor with IC50 of 17 nM, 15-765-fold selectivity other major hepatic CYP enzymes.
DLCI-1 exhibit favorable metabolic stability and half-life in human liver microsomes.
DLCI-1 effectively attenuates intravenous nicotine self-administration in a mouse model.
DLCI-1 may serve as an effective therapeutic to promote tobacco and nicotine cessation.
| M.Wt | 291.234 | |
| Formula | C12H16Cl2N2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yen-Chu Chen, et al. J Pharmacol Exp Ther. 2020 Jan;372(1):21-29.
2. Denton TT, et al. J Med Chem 61:7065–7086.
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