DLCI-1 dihydrochloride

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Chemical Structure : DLCI-1 dihydrochloride

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Catalog No.: PC-49015Not For Human Use, Lab Use Only.

DLCI-1 dihydrochloride is a potent and selective CYP2A6 inhibitor with IC50 of 17 nM, 15-765-fold selectivity other major hepatic CYP enzymes.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DLCI-1 dihydrochloride is a potent and selective CYP2A6 inhibitor with IC50 of 17 nM, 15-765-fold selectivity other major hepatic CYP enzymes.
DLCI-1 exhibit favorable metabolic stability and half-life in human liver microsomes.
DLCI-1 effectively attenuates intravenous nicotine self-administration in a mouse model.
DLCI-1 may serve as an effective therapeutic to promote tobacco and nicotine cessation.

Physicochemical Properties

M.Wt	291.234
Formula	C12H16Cl2N2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-(4-ethylpyridin-3-yl)thiophen-2-yl)methanamine dihydrochloride

References

1. Yen-Chu Chen, et al. J Pharmacol Exp Ther. 2020 Jan;372(1):21-29.

2. Denton TT, et al. J Med Chem 61:7065–7086.

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