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Chemical Structure : DM-PIT-1
CAS No.: 701947-53-7
Catalog No.: PC-62043Not For Human Use, Lab Use Only.
DM-PIT-1 is a specific PIP3 antagonist that disrupts PIP3/Akt PH domain, PIP3/PDK1 PH domain, and PIP3/GRP1 PH domain with IC50 of 27.1 uM, 80.5 uM, and 35.5 uM, respectively.
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| 10 mg | $358 | In stock | |
| 25 mg | $548 | In stock | |
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DM-PIT-1 is a specific PIP3 antagonist that disrupts PIP3/Akt PH domain, PIP3/PDK1 PH domain, and PIP3/GRP1 PH domain with IC50 of 27.1 uM, 80.5 uM, and 35.5 uM, respectively.
DM-PIT-1 suppresses the PI3K-PDK1-Akt pathway and triggers metabolic stress and apoptosis.
DM-PIT-1 inhibits in vivo tumor growth in BALB/c mice.
DM-PIT-1 is a dimethyl analog of PIT-1 with improved aqueous solubility.
| M.Wt | 345.4 | |
| Formula | C16H15N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[[(2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-3,5-dimethyl-benzamide |
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1. Miao B, et al. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.
2. Skidan I, et al. Drug Deliv. 2009 Jan;16(1):45-51.
3. Miao B, et al. Oncogene. 2012 Sep 27;31(39):4317-32.
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