DMI46 | DNMT1 inhibitor | Probechem Biochemicals

Chemical Structure : DMI46

DMI46 (DMI-46)

Catalog No.: PC-26538Not For Human Use, Lab Use Only.

DMI46 is a potent, selective inhibitor of DNA methyltransferase 1 (DNMT1), reverses cancer-specific DNA methylation abnormalities and tumor suppressor genes (TSGs) silencing, leading to robust antileukemic effects.

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Biological Activity

Physicochemical Properties

M.Wt	533.65
Formula	C27H31N7O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(6-((2-amino-1-(4-methoxyphenyl)-2-oxoethyl)thio)-3,5-dicyano-4-ethyl-1H-pyrrolo[2,3b]pyridin-1-yl)-N-(2-(dimethylamino)ethyl)-N-methylacetamide

References

1. Tang S, et al. Proc Natl Acad Sci U S A. 2026 Apr 14;123(15):e2532472123.

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DMI46 (DMI-46)

Biological Activity

Physicochemical Properties

References

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