DMT1 inhibitor 14a | DMT1 inhibitor | Probechem Biochemicals

Chemical Structure : DMT1 inhibitor 14a

DMT1 inhibitor 14a (XEN602 analog 3)

Catalog No.: PC-38325Not For Human Use, Lab Use Only.

DMT1 inhibitor 14a is a potent inhibitor of divalent metal transporter 1 (DMT1) with IC50 of 340 nM in calcein fluorescence assay.

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Biological Activity

DMT1 inhibitor 14a is a potent inhibitor of divalent metal transporter 1 (DMT1) with IC50 of 340 nM in calcein fluorescence assay.
DMT1 inhibitor 14a demonstrated significant iron absorption inhibition in vivo with both 25 and 50 mg/kg doses in an acute rat model of iron hyperabsorption.

Physicochemical Properties

M.Wt	346.467
Formula	C16H15FN4OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	C,C′-[Oxybis(2,1-phenylenemethylene)] dicarbamimidothioate

References

1. Zaihui Zhang, et al. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5108-13.

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DMT1 inhibitor 14a (XEN602 analog 3)

Biological Activity

Physicochemical Properties

References

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