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Chemical Structure : DMT1 inhibitor 14a
Catalog No.: PC-38325Not For Human Use, Lab Use Only.
DMT1 inhibitor 14a is a potent inhibitor of divalent metal transporter 1 (DMT1) with IC50 of 340 nM in calcein fluorescence assay.
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DMT1 inhibitor 14a is a potent inhibitor of divalent metal transporter 1 (DMT1) with IC50 of 340 nM in calcein fluorescence assay.
DMT1 inhibitor 14a demonstrated significant iron absorption inhibition in vivo with both 25 and 50 mg/kg doses in an acute rat model of iron hyperabsorption.
| M.Wt | 346.467 | |
| Formula | C16H15FN4OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zaihui Zhang, et al. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5108-13.
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