DMT1 inhibitor 6b |CAS:1062598-09-7 Probechem Biochemicals

Chemical Structure : DMT1 inhibitor 6b

DMT1 inhibitor 6b (XEN602 analog 2)

Catalog No.: PC-38324Not For Human Use, Lab Use Only.

DMT1 inhibitor 6b is a potent inhibitor of divalent metal transporter 1 (DMT1) with IC50 of 80 nM in calcein fluorescence assay.

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Biological Activity

DMT1 inhibitor 6b is a potent inhibitor of divalent metal transporter 1 (DMT1) with IC50 of 80 nM in calcein fluorescence assay.
DMT1 inhibitor 6b demonstrated significant iron absorption inhibition in vivo with both 25 and 50 mg/kg doses in an acute rat model of iron hyperabsorption.

Physicochemical Properties

M.Wt	380.518
Formula	C16H17FN4S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES

References

1. Zaihui Zhang, et al. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5108-13.

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DMT1 inhibitor 6b (XEN602 analog 2)

Biological Activity

Physicochemical Properties

References

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