Catalog No.: PC-49564Not For Human Use, Lab Use Only.
DN-1289 (DN1289) is a potent, selective and CNS-penetrant dual inhibitor of leucine zipper kinase (DLK, MAP3K12) and leucine zipper-bearing kinase (LZK, MAP3K13) with IC50 of 17 nM and 40 nM, respectively.
DN-1289 (DN1289) is a potent, selective and CNS-penetrant dual inhibitor of leucine zipper kinase (DLK, MAP3K12) and leucine zipper-bearing kinase (LZK, MAP3K13) with IC50 of 17 nM and 40 nM, respectively.
DN-1289 exhibits EC50 of 88 nM and 711 nM in DLK and LZK phospho c-Jun cellular assays, repectively.
DN-1289 dose-dependently protected axons and prevented caspase activation with full axon protection at 1 μM and partial effect at 0.1 and 0.3 μM in DRG neurons.
DN-1289 150 mg/kg (p.o., b.i.d.) significantly attenuated ONC-induced p-c-Jun elevation in the retina in mice.
DN-1289 (100 mg/kg, 5 days) exhibited neuroprotective effect in the SOD1G93A mouse model, with significant elevation of the p-c-Jun level and increased expression of genes associated with DLK pathway activation in the SOD1G93A spinal cords.
