Chemical Structure : DN203316
CAS No.:
2982696-04-6
DN203316
(DN-203316)
Catalog No.: PC-26999Not For Human Use, Lab Use Only.
DN203316 is a potent, selective peroxisome proliferator-activated receptor delta (PPARδ) agonist with EC50 of 0.02 uM (hPPARδ).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DN203316 is a potent, selective peroxisome proliferator-activated receptor delta (PPARδ) agonist with EC50 of 0.02 uM (hPPARδ).
DN203316 attenuates cholesterol-induced ferroptosis in hepatocytes, without detectable toxicity.
DN203316 restores expression of xCT and GPX4 at both the transcript and protein levels and increases GSH levels in cholesterol-exposed hepatocytes.
DN203316 reduces exosomal dsDNA release from ferroptotic hepatocytes and inhibits STING-driven fibrogenesis in MASH.
DN203316 (3 mg/kg/day, i.p.) alleviates MASH by suppressing ferroptosis and STING-driven fibrogenesis in HFHC-induced MASH mice.
Physicochemical Properties
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M.Wt
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440.46
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Formula
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C19H15F3N2O3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(2-methyl-4-(((5-(4-(trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)methyl)thio)phenoxy)acetic acid
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References
1. Kim YJ, et al. Exp Mol Med. 2026 Jun 5. doi: 10.1038/s12276-026-01740-0.
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