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DNDI-8219

Chemical Structure : DNDI-8219

CAS No.: 2222660-40-2

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DNDI-8219 (DNDI8219)

Catalog No.: PC-63237Not For Human Use, Lab Use Only.

DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don).
    DNDI-8219 also has IC050 of 0.53 and 0.15 uM against L. inf and T. cruzi.
    DNDI-8219 displayes promising activity in the more stringent Leishmania infantum hamster model, with better solubility and pharmacokinetic properties, as well as minimal hERG inhibition.

    Physicochemical Properties

    M.Wt 345.234
    Formula C13H10F3N3O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-nitro-6-(4-(trifluoromethoxy)phenoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

    References

    1. Thompson AM, et al. J Med Chem. 2018 Mar 22;61(6):2329-2352.

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