DNMT2 inhibitor 16

Chemical Structure : DNMT2 inhibitor 16

Catalog No.: PC-25447Not For Human Use, Lab Use Only.

DNMT2 inhibitor 16 is a potent, selective DNMT2 (TRDMT1) inhibitor with ITC KD of 3.04 uM, reduces m5C levels in MOLM-13 tRNA and synergizes with doxorubicin to impair cell viability, targeting a cryptic allosteric binding site.

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Biological Activity

Physicochemical Properties

M.Wt	499.01
Formula	C26H31ClN4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((1-((4-((2-amino-2-oxoethyl)amino)-1-(4-chlorophenyl)-4-oxobutan-2-yl)carbamoyl)cyclopropyl)methyl)-4-ethylbenzamide

References

1. Frey AF, et al. iScience. 2025 Aug 5;28(9):113300.

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