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Chemical Structure : DS-437
CAS No.: 1674364-87-4
Catalog No.: PC-35043Not For Human Use, Lab Use Only.
DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $398 | In stock | |
| 100 mg | Get quote |
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DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases.
DS-437 inhibits methylation of full-length histone 4 by PRMT5-MEP50 with an IC50 of 37 ± 1.2 μM in a biochemical assay.
DS-437 inhibits symmetrical dimethylation of PRMT5 substrates in cells.
| M.Wt | 397.454 | |
| Formula | C15H23N7O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-[2-[[(2S,3R,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea |
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1. Smil D, et al. ACS Med Chem Lett. 2015 Mar 2;6(4):408-12.
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