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DS0464

Chemical Structure : DS0464

CAS No.:

DS0464 (DS-0464, DS 0464)

Catalog No.: PC-72806Not For Human Use, Lab Use Only.

DS0464 is a selective, bisubstrate competitive inhibitor SARS-CoV-2 nonstructural protein 14 (nsp14) with IC50 of 1.1 uM, also selective against 28 out of 33 RNA, DNA, and protein MTases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DS0464 is a selective, bisubstrate competitive inhibitor SARS-CoV-2 nonstructural protein 14 (nsp14) with IC50 of 1.1 uM, also selective against 28 out of 33 RNA, DNA, and protein MTases.

    Physicochemical Properties

    M.Wt 473.552
    Formula C21H27N7O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(2-((((2S,3S,4R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)ethyl)-3-phenethylurea

    References

    1. Kanchan Devkota, et al. SLAS Discov. 2021 Oct;26(9):1200-1211.

    2. Devkota K, et al. bioRxiv. 2021 Feb 19:2021.02.19.424337.

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