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DS08701581

Chemical Structure : DS08701581

CAS No.:

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DS08701581 (DS 08701581)

Catalog No.: PC-22693Not For Human Use, Lab Use Only.

DS08701581 is a highly potent inhibitor of feline sarcoma-related (FER) tyrosine kinase with IC50 of 0.32 nM, shows in vivo antitumor efficacy.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DS08701581 is a highly potent inhibitor of feline sarcoma-related (FER) tyrosine kinase with IC50 of 0.32 nM, shows in vivo antitumor efficacy.
DS08701581 shows potent cell-free and cell activities in this template, good oral BA, and improved kinase selectivity, resulting in significant tumor growth inhibition in the Ba/F3-FER tumor model without body weight loss.

Physicochemical Properties

M.Wt 488.60
Formula C26H32N8O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-(((1R,2S)-2-aminocyclohexyl)amino)-5-((3-((2S,6R)-2,6-dimethylmorpholino)phenyl)amino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazine-8-carbonitrile

References

1. Toru Taniguchi, et al. ACS Med Chem Lett. 2024 Jun 13;15(7):1010-1016.

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