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DS42450411

Chemical Structure : DS42450411

CAS No.: 2247168-13-2

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DS42450411 (DS 42450411;DS-42450411)

Catalog No.: PC-35671Not For Human Use, Lab Use Only.

DS42450411 (DS 42450411, DS-42450411) is a potent, orally active hepcidin production inhibitor with IC50 of 32 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DS42450411 (DS 42450411, DS-42450411) is a potent, orally active hepcidin production inhibitor with IC50 of 32 nM.
    The inhibition of hepcidin production of DS42450411 was suggested to be through the inhibition of DYRK1a or a kinase belonging to CMGC family.
    DS42450411 shows serum hepcidin-lowering effects in a mouse model of interleukin-6-induced acute inflammation.

    Physicochemical Properties

    M.Wt 348.494
    Formula C22H28N4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-{1-[(1R,4R)-4-aminocyclohexyl]ethenyl}-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4-amine

    References

    1. Fukuda T, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3333-3337.

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