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Chemical Structure : DS42450411
Catalog No.: PC-35671Not For Human Use, Lab Use Only.
DS42450411 (DS 42450411, DS-42450411) is a potent, orally active hepcidin production inhibitor with IC50 of 32 nM.
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DS42450411 (DS 42450411, DS-42450411) is a potent, orally active hepcidin production inhibitor with IC50 of 32 nM.
The inhibition of hepcidin production of DS42450411 was suggested to be through the inhibition of DYRK1a or a kinase belonging to CMGC family.
DS42450411 shows serum hepcidin-lowering effects in a mouse model of interleukin-6-induced acute inflammation.
| M.Wt | 348.494 | |
| Formula | C22H28N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fukuda T, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3333-3337.
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