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Chemical Structure : DS44470011
Catalog No.: PC-22355Not For Human Use, Lab Use Only.
DS44470011 is a potent, selective hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with IC50 of 1.5 uM for HIF-PHD2, induces erythropoietin (EPO) release in Hep3B cells with EC50 of 8.4 uM.
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DS44470011 is a potent, selective hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with IC50 of 1.5 uM for HIF-PHD2, induces erythropoietin (EPO) release in Hep3B cells with EC50 of 8.4 uM.
DS44470011 is effective at inducing EPO release from cells and in vivo,with EPO10 value of 2.2 mg/kg, more potent than FG-2216.
| M.Wt | 377.40 | |
| Formula | C21H19N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fukuda T, et al. Bioorg Med Chem Lett. 2024 May 14:129799.
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