Catalog No.: PC-21100Not For Human Use, Lab Use Only.
DSHN is a small molecule activator of small heterodimer partner (SHP, NR0B2), functions as a transcriptional activator of SHP, inhibits HCC metastasis via SHP-mediated repression of Ccl2 signaling.
DSHN is a small molecule activator of small heterodimer partner (SHP, NR0B2), functions as a transcriptional activator of SHP, inhibits HCC metastasis via SHP-mediated repression of Ccl2 signaling.
DSHN markedly reactivates Shp expression in both mouse (Nmuli, Hepa-1) and human (MHCC97H) hepatic cells in which Shp expression is lost.
DSHN activates Shp promoter luciferase reporter and augments the transactivation of several known Shp activators dose-dependently, including live receptor homolog 1 (LRH-1), hepatocyte nuclear factor 4α (HNF4α), and retinoid X receptor/retinoic acid receptor α (RXR/RARα).
DSHN also increases SHP protein half-life, prevents SHP protein ubiquitination and degradation.
DSHN is a potent activator of SHP through both transcriptional and post-transcriptional regulation.
DSHN (50 uM) inhibits CCl2-mediated HCC cell invasion and migration in Huh7 cells.
