Chemical Structure : DSHN
CAS No.:
313952-63-5
DSHN
(NR0B2 agonist DSHN)
Catalog No.: PC-21100Not For Human Use, Lab Use Only.
DSHN is a small molecule activator of small heterodimer partner (SHP, NR0B2), functions as a transcriptional activator of SHP, inhibits HCC metastasis via SHP-mediated repression of Ccl2 signaling.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DSHN is a small molecule activator of small heterodimer partner (SHP, NR0B2), functions as a transcriptional activator of SHP, inhibits HCC metastasis via SHP-mediated repression of Ccl2 signaling.
DSHN markedly reactivates Shp expression in both mouse (Nmuli, Hepa-1) and human (MHCC97H) hepatic cells in which Shp expression is lost.
DSHN activates Shp promoter luciferase reporter and augments the transactivation of several known Shp activators dose-dependently, including live receptor homolog 1 (LRH-1), hepatocyte nuclear factor 4α (HNF4α), and retinoid X receptor/retinoic acid receptor α (RXR/RARα).
DSHN also increases SHP protein half-life, prevents SHP protein ubiquitination and degradation.
DSHN is a potent activator of SHP through both transcriptional and post-transcriptional regulation.
DSHN (50 uM) inhibits CCl2-mediated HCC cell invasion and migration in Huh7 cells.
Physicochemical Properties
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M.Wt
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323.36
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Formula
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C15H17NO5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(diethylsulfamoyl)-3-hydroxynaphthalene-2-carboxylic acid
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References
1. Yang Z, et al. Mol Cancer Ther. 2016 Oct;15(10):2294-2301.
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