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DSM161

Chemical Structure : DSM161

CAS No.: 1163260-84-1

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DSM161 (DSM 161)

Catalog No.: PC-49849Not For Human Use, Lab Use Only.

DSM161 (DSM 161) is a high potent A. baumannii DHODH (AbDHODH) inhibitor, has MIC <1 ug/mL against geographically diverse A. baumannii strains, including meropenem-resistant isolates.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DSM161 (DSM 161) is a high potent A. baumannii DHODH (AbDHODH) inhibitor, has MIC <1 ug/mL against geographically diverse A. baumannii strains, including meropenem-resistant isolates.
    DSM161 has a long in vivo half-life (vs DSM186) conferred significant protection in the neutropenic mouse thigh infection model.

    Physicochemical Properties

    M.Wt 351.30
    Formula C12H10F5N5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-methyl-N-(4-(pentafluoro-l6-sulfaneyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

    References

    1. Russo TA, et al. Proc Natl Acad Sci U S A. 2022 Dec 20;119(51):e2213116119.

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