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DSM705

Chemical Structure : DSM705

CAS No.: 2653225-38-6

DSM705 (DSM 705)

Catalog No.: PC-20261Not For Human Use, Lab Use Only.

DSM705 (DSM 705) is a potent, highly selective, long-duration and orally bioavailable malaria DHODH inhibitor with IC50 of 95 nM (PfDHODH).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DSM705 (DSM 705) is a potent, highly selective, long-duration and orally bioavailable malaria DHODH inhibitor with IC50 of 95 nM (PfDHODH), and 52 nM (P. vivax DHODH).
DSM705 shows no inhibition of mammalian DHODHs. DSM705 shows inhibitory activity against P. falciparum Pf3D7 cells (EC50=12 nM).
DSM705 (50 mg/kg, p.o.) fully suppresses parasitemia in vivo.

Physicochemical Properties

M.Wt 404.39
Formula C19H19F3N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Methyl-N-[(1R)-1-(1H-1,2,4-triazol-5-yl)ethyl]-4-[1-[6-(trifluoromethyl)-3-pyridinyl]cyclopropyl]-1H-pyrrole-2-carboxamide

References

1. Palmer MJ, et, al. J Med Chem. 2021 May 13;64(9):6085-6136.

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