Chemical Structure : DSO-5a
CAS No.:
2765182-03-2
DSO-5a
(Dimethyl Shikonin Oxime 5a)
Catalog No.: PC-20957Not For Human Use, Lab Use Only.
DSO-5a (Dimethyl shikonin oxime 5a) is a potent, selective agonist pf bombesin receptor subtype-3 (BB3, BRS-3) with pEC50 of 8.4 (IP-1 accumulation in hBB3-H1299 cells).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DSO-5a (Dimethyl shikonin oxime 5a) is a potent, selective agonist pf bombesin receptor subtype-3 (BB3, BRS-3) with pEC50 of 8.4 (IP-1 accumulation in hBB3-H1299 cells).
DSO-5a did not elicit detectable calcium response in parental cells but elicited a strong calcium response in hBB3-H1299 cells with a pEC50 value of 7.964, Bantag-1 blocked these calcium responses in a dose-dependent manner.
DSO-5a induced a dose-dependent IP-1 accumulation with a pEC50 value of 7.262 in mBB3-HEK cells.
DSO-5a elicited IP-1 accumulation with pEC50 value of 9.357 in B16 cells.
DSO-5a (3 mg/kg; 10 mg/kg; 30 mg/kg) 30 min before glucose challenge (3 g/kg) reduced blood glucose excursions in a dose-dependent manner in C57BL/6 mice.
Physicochemical Properties
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M.Wt
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440.45
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Formula
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C23H24N2O7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(C1=CC=CO1)OC(C(C(OC)=C2/C3=N/O)=CC(OC)=C2/C(C=C3)=N\O)C(C)(C)C=C
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References
1. Lehao Wu, et al. J Med Chem. 2023 Jun 22;66(12):8011-8029.
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