Catalog No.: PC-38164Not For Human Use, Lab Use Only.
DSRM-3716 (DSRM3716, 5-iodoisoquinoline) is a potent and selective inhibitor of NADase SARM1 with IC50 of 75 nM, displays selectivity against various NAD metabolizing and pathway enzymes (e.g., NAMPT and NMNAT).
DSRM-3716 (DSRM3716, 5-iodoisoquinoline) is a potent and selective inhibitor of NADase SARM1 with IC50 of 75 nM.
DSRM-3716 displays selectivity against various NAD metabolizing and pathway enzymes (e.g., NAMPT and NMNAT).
DSRM-3716 recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy or mitochondrial dysfunction. SARM1 inhibition post-mitochondrial injury with rotenone allows recovery and rescues axons that already entered the metastable state.
DSRM-3716 demontrates the potential to treat axonopathies of the central and peripheral nervous systems by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.
Physicochemical Properties
M.Wt
255.058
Formula
C9H6IN
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-iodoisoquinoline
References
1. Robert O. Hughes, et al. Cell Rep. 2021 Jan 5; 34(1): 108588.
