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Chemical Structure : DT-0111
Catalog No.: PC-20742Not For Human Use, Lab Use Only.
DT-0111 (DT0111) is a selective and effective, water-soluble antagonist at P2X2/3R, does not activate or block P2YR, inhibits ATP-induced current in nodose ganglionic cells with IC50 of 0.3 uM.
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DT-0111 (DT0111) is a selective and effective, water-soluble antagonist at P2X2/3R, does not activate or block P2YR, inhibits ATP-induced current in nodose ganglionic cells with IC50 of 0.3 uM.
DT-0111 markedly inhibited the activation by ATP of nodose pulmonary vagal afferents in vitro.
DT-0111 inhibited aerosolized ATP-induced bronchoconstriction and cough in vivo.
| M.Wt | 670.36 | |
| Formula | C19H25N6O15P3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Amir Pelleg, et al. Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619877960.
2. Patent US 11440935.
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