Catalog No.: PC-72068Not For Human Use, Lab Use Only.
DTHIB (Direct Targeted HSF1 InhiBitor, SISU-102) is a specific small molecule HSF1 inhibitor with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD).
DTHIB (Direct Targeted HSF1 InhiBitor, SISU-102) is a specific small molecule HSF1 inhibitor with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD).
HSF1 is highly expressed in human prostate cancer and is inhibited by DTHIB, suppresses AR activity and signaling.
DTHIB inhibits human prostate cancer cell proliferation (PC-3, EC50=3 uM).
DTHIB inhibits tumor growth in animal models oftherapy-resistant prostate cancer, with no weight loss or organ damage.
Physicochemical Properties
M.Wt
309.681
Formula
C13H9ClFN3O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-(4-Chloro-3-nitrophenyl)-3-(4-fluorophenyl)urea
References
1. Bushu Dong, et al. Sci Transl Med. 2020 Dec 16;12(574):eabb5647.
