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Chemical Structure : DU102
Catalog No.: PC-23016Not For Human Use, Lab Use Only.
DU102 is a potent small molecule inhibitor of small G protein Arf1, binds to the catalytic pocket of the Arf1-GDP-Sec7, inhibit Arf1 activity by binding to Arf1 and Arf-GEF.
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DU102 is a potent small molecule inhibitor of small G protein Arf1, binds to the catalytic pocket of the Arf1-GDP-Sec7, inhibit Arf1 activity by binding to Arf1 and Arf-GEF.
DU102 dramatically reduced the mitochondrial membrane potential in CT26 cells, also promote cell aging cascade in cancer stem cells (CSCs).
DU102 promotes T cell infiltration, activation, and memory T cell population, does not directly kill tumor cells rather than enhances anti-tumor immunity. DU102 inflames the tumor microenvironment, reprogrammes CD8+ T cells into more activated T cells with elevated effector function, reduced exhaustion, increased proliferation, and stronger cytotoxic activity.
DU102 promotes a population of PD-1+TCF1+CD8+ CD4+ stem-like T cells in liver tumors.
DU102 exhibits low toxicity and robust anti-tumor activities in various mouse tumor models, including liver, colon, breast, and melanoma, as well as PDX tumor models.
| M.Wt | 375.49 | |
| Formula | C21H21N5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yuetong Wang, et al. Adv Sci (Weinh). 2024 Sep 3:e2404442.
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