DU172 | A1AR antagonist | Probechem Biochemicals

Chemical Structure : DU172

DU172 (DU-172)

Catalog No.: PC-25473Not For Human Use, Lab Use Only.

DU172 (Compound 23b) is a potent, selective, covalent, irreversible antagonist of A1 adenosine receptor (A1AR), inhibits [3H]DPCPX binding to A1AR with IC50 of 21 nM, 132-fold more selective for the A1AR over the A2AAR.

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Biological Activity

Physicochemical Properties

M.Wt	519.59
Formula	C24H30FN5O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((3-(8-cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetrahydro-3H-purin-3-yl)propyl)carbamoyl)benzenesulfonyl fluoride

References

1. Glukhova A, et al. Cell. 2017 Feb 23;168(5):867-877.e13.

2. Beauglehole AR, et al. J Med Chem. 2000 Dec 28;43(26):4973-80.

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DU172 (DU-172)

Biological Activity

Physicochemical Properties

References

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