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DX2-201

Chemical Structure : DX2-201

CAS No.: 2749554-00-3

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DX2-201 (DX 2-201)

Catalog No.: PC-20964Not For Human Use, Lab Use Only.

DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 312 nM in NAD/NADH assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 312 nM in NAD/NADH assays.
DX2-201 potently inhibits the mitochondrial function by depleting ATP production in MIA PaCa-2 cells when glucose is replaced by galactose in the medium, a condition that forces mammalian cells to rely on OXPHOS.
DX2-201 depletes ATP production with an IC50 value of 118.5 nM in the galactose-containing medium.
DX2-201 inhibits MIA PaCa-2 and BxPC-3 cells growth with IC50 values of 0.4 μM and 0.6 μM, respectively.

Physicochemical Properties

M.Wt 432.55
Formula C18H28N2O6S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C([C@H]1CN(S(=O)(C2=CC=C(S(=O)(N(CC)CC)=O)C=C2)=O)CCC1)OCC

References

1. Ding Xue, et al. Ding Xue, et al. J Med Chem. 2022 Jan 13;65(1):343-368.

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