DX3-234 | OXPHOS inhibitor | Probechem Biochemicals

Chemical Structure : DX3-234

DX3-234 (DX 3-234)

Catalog No.: PC-20780Not For Human Use, Lab Use Only.

DX3-234 is a potent selective complex I oxidative phosphorylation (OXPHOS) inhibitor with IC50 of 42.6 nM in NAD+/NADH assay and IC50 of 29 nM in ATP depletion assay using MIA PaCa-2 cells.

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Biological Activity

DX3-234 is a potent selective complex I oxidative phosphorylation (OXPHOS) inhibitor with IC50 of 42.6 nM in NAD+/NADH assay and IC50 of 29 nM in ATP depletion assay using MIA PaCa-2 cells.
DX3-234 inhibits the growth of MIA PaCa-2 cells with an IC50 value of 70 nM.
DX3-234 shows significant tumor suppression in the Pan02 syngeneic model of pancreatic cancer.

Physicochemical Properties

M.Wt	565.70
Formula	C25H35N5O6S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C([C@H]1CN(S(=O)(C2=CC=C(S(=O)(C3CCC3)=O)C=C2)=O)CCC1)N4CCN(C5=NC(C(C)C)=NO5)CC4

References

1. Ding Xue, et al. J Med Chem. 2022 Jan 13;65(1):343-368.

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DX3-234 (DX 3-234)

Biological Activity

Physicochemical Properties

References

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