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DX314

Chemical Structure : DX314

CAS No.: 1662711-07-0

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DX314 (DX 314)

Catalog No.: PC-72684Not For Human Use, Lab Use Only.

DX314 is a potent, specific CYP26B1 inhibitor with IC50 of 108 nM, >15-fold selectivity over CYP26A1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DX314 is a potent, specific CYP26B1 inhibitor with IC50 of 108 nM, >15-fold selectivity over CYP26A1.
    DX314 potentiates all-trans-RA (atRA) gene expression effects in healthy and diseased reconstructed human epidermis (RHE).
    DX314 potentiates the effects of atRA on the expression and localization of keratin 10 (KRT10), protects barrier function in RHE.
    DX314 reduces comedonal number, induces epidermal thickening, and increases comedonal profile, while having no effect on transepidermal water loss (TEWL) in treated rhino mice.

    Physicochemical Properties

    M.Wt 391.511
    Formula C25H29NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(4-{[3-(adamantan-1-yl)-4-hydroxyphenyl]amino}phenyl)propanoic Acid

    References

    1. Joachim G S Veit, et al. J Invest Dermatol. 2021 Jan;141(1):72-83.e6.

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